電話：
信箱：yifanchen@ncu.edu.tw
研究室：工一舘 E237A
實驗室：生物與軟物質物化實驗室 (E232, 分機34237)
學歷：美國康乃爾大學 物理博士 (2011; advisor: Sol Gruner); 國立台灣大學 化工學士 (2003)
研究領域：軟質材料性質分析、生物物理、軟凝態物質/生物液晶體、Ｘ光散射與單晶繞射學應用、高壓物理應用
研究背景
我們致力於應用同步輻射光源及中子源之散射、晶體繞射技術，結合高壓物理法來探討溶致性液晶體(lyotropic liquid crystals)與生物軟物質(biological soft matter)的結構、動態(dynamics)及相變化行為。我們將從此研究中建立起物質之功能、結構和動態的相互關聯性。此關聯性不但可增進我們對這些物質系統的基礎了解(為科學家們所感興趣)，更有助於功能性材料的設計與開發(乃工程師致力的目摽之ㄧ)。目前我們的研究主題包括：
1. 帶電性磷脂質(electrically charged phospholipids)與其他溶致性液晶體的相變化行為機制
2. 脂質生物膜(lipid biomembrane)之材料性質與動態性質的相互關聯性
3. 發展使用於蛋白質結晶之高壓力低溫冷凍技術(high-pressure cryocooling technique)及開發設計其他科學儀器
4. 水與生物軟物質之相互作用
5. 應用中子源散射技術於生物及新穎材料系統之研究
我們歡迎對上述研究主題有興趣的研究生及專題生。對於由結構上及動態上定性其生物與材料系統有興趣的研究團隊，我們也尋求所有可能的合作機會
論文著作
17. Ko, T. H. & Chen, Y.-F. 2023 "Correlation between the In-plane Critical Behavior and Out-of-plane Interaction of Ternary Lipid Membranes." Membranes, Volume 13, 6.
16. Chang, S. -M., et. al. 2022 "Mechanism of endosomal escape by pH-responsive nucleic-acid vectors." Physical Review E, Volume 106, 034408.
15. Chiou, P. -C., et. al. 2022 "Molecular packing of lipid membranes and action mechanisms of membrane-active peptides." Colloids and Surfaces B: Biointerfaces, Volume 213, 112384.
14. Huang, Y. -J., et. al. 2021 "In-Situ Synchrotron SAXS and WAXS Investigation on the Deformation of Single and Coaxial Electrospun P(VDF-TrFE)-Based Nanofibers." Internationa Journal of Molecular Sciences, Volume 22, 12669.
13. Xie, C. -Z., et. al. 2020 "Uncoupling between the lipid membrane dynamics of differing hierarchical levels." Physical Review E, Volume 101, 012416.
12. Lee, Y. -P., et. al. 2019 "Long-term thermally stable nanoconfining networks for efficient fully T conjugated semicrystalline/amorphous diblock copolymer photovoltaics." Organic Electronics, Volume 69, p263-274.
11. Chang, W. -F., et. al. 2018 "Correlation of an antimicrobial peptide’s potency and its influences on membrane elasticity." Physical Review E, Volume 98, 042408.
10. Tsai, C. -W., et. al. 2018 "Development of an indolicidin-derived peptide by reducing membrane perturbation to decrease cytotoxicity and maintain gene delivery ability." Colloids and Surfaces B: Biointerfaces, Volume 165, 18.
9. Tsang, K. -Y., et. al. 2017 "Coupling of lipid membrane elasticity and in-plane dynamics." Physical Review E, Volume 96, 012410.
8. Muduli, S., et. al. 2017 "Proliferation and osteogenic differentiation of amniotic fluid-derived stem cells." Journal of Materials Chemistry B, Volume 5, 5345.
7. Fan, Z. -A., et. al. 2016 "Revisit the Correlation between the Elastic Mechanics and Fusion of Lipid Membranes." Scientific Reports (Nature Publishing Group), Volume 6, 31470.
6. Chen, Y. -F.*, et. al. 2015. "Differential Dependences on [Ca2+] and Temperature of the Monolayer Spontaneous Curvatures of DOPE, DOPA and Cardiolipin: Effects of Modulating the Strength of the Inter-headgroup Repulsion." Soft Matter, Volume 11, p4041-4053.
5. Liu, C. Y., et. al. 2014. "PEGylation Site-Dependent Structural Heterogeneity Study of MonoPEGylated Human Parathyroid Hormone Fragment hPTH(1-34)." Langmuir, Volume 30, p11421-11427.
4. Lee, Y. H., et. al. 2014. "Phase transformation and self-assembly behavior of supramolecular rod comb block copolymers." Polymer, Volume 55, p2481-2490.
3. Lee, Y. H., et. al. 2014. "A new strategy for co-assembling pi-conjugated polymer/cadmium sulfide hybrids into an efficient charge-transporting nanochannel array by using an all-conjugated diblock copolymer motif." Journal of Materials Chemistry A, Volume 2, p14600-14612.
2. Lai, Y. -C.; Chen, Y. -F.; Chiang, Y. -W. 2013. "ESR Study of Interfacial Hydration Layers of Polypeptides in Water-Filled Nanochannels and in Vitrified Bulk Solvents." PLoS ONE, Volume 8, e68264.
1. Yu, C. F.; Chao, D. S.; Chen, Y. -F.; Liang, J. H. 2013. "Photoluminescent Characteristics of Ion Beam Synthesized Ge Nanoparticles in Thermally Grown SiO2 Films." Nuclear Instruments & Methods in Physics Research B, Volume 307, p171-176.
研究計畫
專利