專任教師
陳文逸教授-兼藝文中心主任
生物分子辨識工程實驗室
學校分機:34222
信箱:wychen@ncu.edu.tw
詳細介紹

電話:34222
信箱:wychen@ncu.edu.tw
研究室:工四館 E3-302
實驗室:生物分子辨識工程實驗室 E3-325
實驗室網站:https://biorecognition3422.wixsite.com/34222
學歷:美國奧克拉荷馬州立大學化學工程博士
研究領域:生物辨識系統之熱力學與動力學、藥物控制釋放 生醫材料於幹細胞之純化與培養、生物晶片

 研究背景

Dr. Wen-Yih Chen is currently a Distinguished Professor in the Department of Chemical and Materials Engineering and Institute of Biomedical Engineering, National Central University (NCU). He was the Chairman of the Department and was the Associated Dean of the Engineering School of NCU. He also was a visiting Professor of MIT, Monash University and U. of Washington, Seattle. His research emphases have been on understanding the thermodynamics and kinetics between biomolecular interactions. With the principle understanding of the molecular interactions, he has successfully elucidated some biochemical separations and protein folding disease phenomena in molecular level. Currently, he has devoted his research resources in biosensor development, especially in gene sequencing and biomarkers detection by Field Effect Transistor and Surface Plasmon Resonance. He has published more than 150 peer review papers and owned more than 40 patents, mostly in biosensor area. He is currently on the editorial board of Biotechnology Journal (SCI), Bioprocess and Bioengineering (SCI) and Atomic and Molecular Physics (SCI). He is one of the founders of a newly established company, Helios Bioelectronics Inc., Taiwan.
 獲獎紀錄

      社團法人台灣生物技術與生化工程學會(2019 傑出研究獎)
      中國工程師學會傑出工程教授獎 (2019)
     
 科技部研究傑出獎 (2018)

      德國紐倫堡發明獎金牌 “抗生物沾黏之塗佈組成物、抗生物沾黏薄膜及  抗生物沾黏薄膜之製造方法 (2018)

      台灣生物技術與生化工程學會學術獎(2017)

      國立中央大學專利績優獎 (2008, 2012)

       國立中央大學績優技術移轉獎(2009)

       台灣聯合大學-榮總研究計畫優良成果獎

       國立中央大學特聘教授(2005~2014, 2019~)

 論文著作
  Journal (2010~present)​​​​​​

  1. ​​​​​Tsai-Ling Li, Meng-Wei Wu, Chian-Hui Lai, Yu-Hsuan Chang, Li-Jen Su, Wen-Yih Chen “Designed phosphate-methylated oligonucleotides as PCR primers for SNP discrimination” Analytical Biochemistry (Accepted) (2019)
  2. Vaida Paketuryte, Vaida Linkuviene, Georg Krainer, Wen-Yih Chen and Daumantas Matulis “Repeatability, precision, and accuracy of the enthalpies and Gibbs energies of a protein-ligand binding reaction measured by isothermal titration calorimetry” European Biophysics Journal  (https://doi.org/10.1007/s00249-018-1341-z) (2018)
  3. Tai-Chi Kuo, Yu-Chiang Huang, Daumantas Matulis and Wen-Yih Chen* “Molecular Self-Interactions of Ribonuclease A Revealed by Isothermal Titration Calorimetry and Self-Interaction Chromatography - Effects of Anisotropy of Protein Surface Charge” Journal of the Taiwan Institute of Chemical Engineers (https://doi.org/10.1016/j.jtice.2018.12.008 (2018)
  4. Lina Baranauskiene, Tai-Chih Kuo, Wen-Yih Chen* and Daumantas Matulis “Isothermal titration calorimetry for characterization of recombinant protein” Current Opinion in Biotechnology, 55, 9-15 (2018) (IF: 8.330) (5/407: Biomedical Engineering)
  5. CJ Huang, ZE Lin, YS Yang, H W-H Chan, W.-Y. Chen* “Neutralized Chimeric DNA Probe for Detection of Single Nucleotide Polymorphism on Surface Plasmon Resonance Biosensor” Biosensors and Bioelectronic 99, 170-175 (2018) (IF:7.78) (2/76: Chemistry, Analytical)
  6. WP Hu, CC Tsai, YS Yang, H W-H Chan and WY Chen* “Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe” Scientific Reports (2018) 8:12598 (IF:4.122) (12/64: Multi-disciplinary Science)
  7. Hui-Ting Lin, Wei Yang, Wen-Yu Su, Chun-Ju Chan, Wen-Yih Chen, Jeffrey J. P. Tasi and Wen-Pin Hu “Study on the Binding Ability of Truncated Aptamers for the Prostate Specific Antigen Using Both Computational and Experimental Approaches” FC 2017, LNEE 464, pp. 46–55, (2018) (https://doi.org/10.1007/978-981-10-7398-4_5)
  8. Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Heffrey J.P. Tsai and Wen-Pin Hu “The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen” BioMed Research International, doi.org/10.1155/2017/5041683 (2017)
  9. Vaida Linkuviene, Georg Kranier, Wen-Yih Chen and Daumantas Matulis “Isothermal titration calorimetry for drug design:  Precision of enthalpy and binding constant easurements and comparison of the instruments” Analytical Biochemistry 515, 61-64 (2016)
  10. Tzu-Cheng Sung, Wen-Yih Chen, Pramod Shah and Chien-Sheng Chen “Replaceable liposomal aptamer for the ultrasensitive and rapid detection of biotin” Scientific Report. DOI:0.1038/srep21369 (2016)
  11. Tai-Chih Kuo, Ching-Wei Tsai, Peng-Chen Lee, Wen-Yih Chen* “Revisiting the streptavidin–biotin binding by using an aptamer and displacement isothermal calorimetry titration” J. Mol. Recog. 28, 125-128 (2015)
  12. CW Tsai, WW Hu, CI Liu, RC Ruaan, BC Tsai, SL Jin, Y Chang, WY Chen* “The consideration of Indolicidin modification to balance its hemocompatibility and delivery efficiency” International Journal of Pharmaceutics 494(1) 498-505 (2015)
  13. WP Hu, J V Kumar; CJ Huang, WY Chen* “Computational selection of RNA aptamers against angiopoietin-2 and experimental evaluation” Biochemical and Biomedical Research International, 1-8, (2015)
  14. SB Yeh, Chien-Sheng Chen, Wen-Yih Chen*, and Chun-Jen Huang* “Modification of Silicone Elastomer with Zwitterionic Silane for Durable Antifouling Properties” Langmuir 30 (38), 11386-11393 (2014)
  15. Chih-Ying Liu, Xin Li, Wen-Yih Chen, Li-Chiao Chang, Yi-Fan Chen, Hsin-Lung Chen, Ya-Sen Sun, Hsiu-Yun Lai, E-Wen Huang, “PEGylation Site-dependent Structural-heterogeneity Study of MonoPEGylated Human Parathyroid Hormone Fragment hPTH(1-34)” Langmuir 30(38), 11421-11427 (2014)
  16. SF Lin, FC Chang, ZH Chen, CM Wang, TH Yang, WY Chen* and JY Chang* “A polarization control system for intensity-resolved guided mode resonance sensors” Sensors, 14(3), 5198-5206 (2014)
  17. CW Tsai, SL Jheng, WY Chen* and RC Ruaan* “Strategy of Fc-Recognizable Peptide Ligand Design for Oriented Immobilization of Antibody” Analytical Chemistry 86(6), 2931-2938 (2014)
  18. SK Chen, CA Chung, YC Cheng, CJ Huang, WY Chen, RC Ruaan, C Li, CW Tsao, WW Hu, and CC Chien “Toll-like Receptor 6 and Connective Tissue Growth Factor are significantly upregulated in mitomycin-C treated urothelial carcinoma cells under hydrostatic pressure stimulation” Genetic Testing and Molecular Biomarkers, 18(6), 410-416 (2014)
  19. Hu WP, Huang LY and Chen WY* “Optimal Buffer pH Value on the Detection of HAS by using a Protein Chip Prepared by DNA-directed Immobilization” Applied Mechanics and Materials, 284-287, 398-402 (2013)
  20. Chen WY*, Hsu MY, Tasi CW, Ruaan RC, Kao WH, Chung Chuan HYT “Kosmotrope-like Hydration behavior of Polyethylene Glycol- Evidences of Microcalorimetry and Binding Isotherm Measurements” Langmuir, 2;29(13) 4259-65 (2013)
  21. Chen WY*, Chen HC, Yang YS, Huang CJ, and Hu WP “Improved DNA detection by utilizing electrically neutral DNA probe in field-effect transistor measurement as evidence by surface plasmon resonsnce imaging” Biosensors and Bioelectronics 41,795-801 (2013)
  22. Kuo TC, Lee PC and Chen WY* “Salt bridge exchange binding mechanism between streptavidin and its DNA aptamer – thermodynamics and spectroscopic evidences” J. Molecular Recognition, 26, 149-159 (2013) (SCI)
  23. Lin SF, Wang CM, Tsai YL, Ding TJ, Yang TH, Chen WY, Yeh S F and Chang JY, “A model for fast predicting and optimizing the sensitivity of surface-relief guided mode resonance sensors”, Sensors and Actuator B, 176, 1197-1203 (2013) (SCI)
  24. Chen SK, Chung CA, Cheng YC, Huang CJ, Ruaan RC, Chen WY, Li Chuan, Tsao CW, Hu WW, and Chien CC “Hydrostatic pressure enhances mitomycin C- induced apoptosis in urothelial carcinoma cells” Urologic Oncology, 32(1), 17-24 (2012)
  25. Tsai CW, Kao WH, Chang LC, Ruaan RC, and Chen WY*, “Structural Stability-Chromatographic Retention Relationship on Exenatide Diastereomers Separation”, Analytical and Bioanalytical Chemistry 404(8), 2437-44. (2012)  (SCI)
  26. Tsai CW, Chen WY*, Ruaan RC* “Retention Prediction of Peptide Enantiomers in Reversed-Phase Liquid Chromatography Assisted by Molecular Dynamics Simulation” Langmuir, 2012 (Accepted) (SCI)
  27. Hu WW, Syu WJ, Chen WY, Ruaan RC, Cheng YC, Chien CC, Li C, Chung CA, and Tsao CW “Use of Biotinylated Chitosan for Substrate-Mediated Gene Delivery” Bioconjugate Chemistry 15;23(8), 1587-99. (2012) (SCI)
  28. Tsai MC, Wu JY, Lin HC, Chen TH, Hsieh YH, Shih CM, Chen WY, Huang RN and Kuo TC* “The use of a kinesin-cro fusion protein as the nano shuttle to transport specific DNA” Current Nanoscience 8, 669-675(2012) (SCI)
  29. Lin SF, Chen WY*, Chang TY* “Sensitive metal layer assisted guided mode resonance biosensor with a spectrum inversed response and strong asymmetric resonance field distribution” Optics Express, 20, 14584-14595, 2012 (SCI)
  30. Chang Y, Chang Y, Higuchi A, Shih YJ, Li PT, Chen WY, Tasi EM and Hsiue GH “Bioadhesive control of plasma proteins and blood cells from umbilical cord blood onto the interface grafted with zwitterionic polymer brushes” Langmuir, 28(9), 4309-4317, 2012 (SCI)
  31. Lin PH, Tsai CW, Wu J.W., Ruaan RC, and Chen WY*, “Molecular Dynamics Simulation of Induced-Fit Binding Process of DNA Aptamer and L-Argininamide”, Biotechnology Journal, 7, 1367–1375, 2012 (SCI)
  32. Tsao CW, Lin CH, Cheng YC, Chien CC, Chang CC and Chen WY* “Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry” Analyst, 137 (11), 2643 – 2650 (2012) (SCI)
  33. Chiang YC, Chang Y, Chen WY, and Ruaan RC, “Biofouling Resistance of Ultrafiltration Membranes Controlled by Surface Self-Assembled Coating with PEGylated Copolymers”, Langmuir 28, 1399-1407 (2012) (SCI)
  34. Hu WP, Huang LY, Kuo TC, Hu WW, Chang Y, Chen CS, Chen HC, Chen WY*      “Optimization of DNA Directed Immobilization on Mixed oligo (ethylene glycol) (OEG) Monolayers for Immunodetection”, Analytical Biochemistry 423, 26–35 (2012) (SCI)
  35. Cheng YC, Chen KH, Wang JS, Hsu WL, Chien CC, Chen WY, and Tsao CW, “Rapid Analysis of Abused Drugs Using Nanostructured Silicon Surface Assisted Laser Desorption/Ionization Mass Spectrometry”, Analyst 137 (3), 654-661 (2012) (SCI)
  36. Chen WY, Huang JT, Cheng YC, Chien CC, and Tsao CW, “Fabrication of nanostructured silicon by metal-assistend etching and its effects on matrix-free laser desorption/ionization mass spectrometry”, Analytical Chimica Acta, 687, 97-104, (2011) (SCI)
  37. Wang SSS, Lin MS, Fang YH, Lee KW, Chen SL, and Chen WY*, “Using isothermal titration calorimetry to real-time monitor the heat of metabolism: a case study using PC12 cells and Aβ (1-40)”, Colloid and Surface B: Biointerface, 83, 307-312, (2011) (SCI)
  38. Liu JT, Lin PS, Hsin YM, Tsai JZ, Chen WY “Surface plasmon resonance biosensor for microalbumin detection” Journal of the Taiwan Institute of Chemical Engineers, 42, 696-700 (2011) (SCI)
  39. Lin SF, Ding TJ, Liu JT, Lee CC, Yang TH, Chen WY* and Chang JY* “A Guided Mode Resonance Aptasensor for Thrombin Detection” Sensors 11, 8953-8965 (2011) (SCI)
  40. Higuchi, A, Lee JH, Wang Y, Chen WY, Ling QD, and Chang Y “Evaluation of bioactivity and effect of polymeric stabilizers during heat treatment for the unfolded fraction of human epidermal growth factor” Sen’I Gakkaishi, 67(8), 185-191, 2011 (SCI)
  41. Lue JH, Ding TJ, Yang TH, Chang JY, and Chen WY “Real-time Monitoring on Peptide Synthesis by GMR Biosensors” Proceedings - 2011 4th International Conference on Biomedical Engineering and Informatics, BMEI 4, 1858-1861 (2011) (SCI)
  42. Tsai, J.-Z., Chen, C.-J., Liu, J.-T., Hsin, Y.-M., Chen, WY, Hsueh, K.-H. “Development of capacitance measurement system for human serum albumin detection” Electronics Letters 46 (10) , 678-680 (2010)
  43. Huang HI, Cheng YC, Chen WY, Tsao CW, Huang CJ, Liu HT, and Chien CC*, “Comparative proteomic analysis of Placenta-Derived Multipotent Cells (PDMCs) and its differentiated Neuron”, The Chinese Journal of Pain, 20, 1-11, (2010) (SCI)
  44. Lin PH, Kao YH, Chang Y, Cheng YC, Chien CC, and Chen WY*, “Daunomycin interaction with DNA: Microcalorimetric studies of the thermodynamics and binding mechanism”, Biotechnology Journal, 5, 1069-1077, (2010) (SCI)
  45. Chang Y*, Yandi W, Chen WY, Shih YJ, Yang CS, Chang Y, Ling QD, and Higuchi A, “Tunable Bioadhesive copolymer hydrogels of thermoresponsive poly(N-isopropyl acrylamide) containing zwitterionic polysulfobetaine”, Biomacromolecules, 11, 1101-1110, (2010) (SCI)
  46. Hung YT, Lin MS, Chen WY, and Wang SSS*, “Investigating the Effects of Sodium Dodecyl Sulfate on the Aggregative Behavior of Hen Egg-White Lysozyme at Acidic pH”, Colloids and Surfaces B: Biointerfaces, 81, 141-151, (2010) (SCI)
  47. Higuchi A, Siao YD, Yang ST, Hsieh PV, Fukushima H, Chang Y, and Chen WY*,  “Peroxidase Activity of DNA Aptamer-Pt Complexes Prepared with Cisplatin”, Journal of Biomaterials Science: Polymer Edition, 21, 67-82, (2010) (SCI)
  48. Chang Y, Shu SH, Shih YJ, Chu CW, Ruaan RC, and Chen WY*, “Hemocompatible Mixed-Charge Copolymer Brushes of Pseudozwitterionic Surfaces Resistant to Nonspecific Plasma Protein Fouling”, Langmuir, 26, 3522–3530, (2010) (SCI)
  49. Roselin LS, Lin MS, Lin PH, Chang Y, and Chen WY*, “Recent trends and some applications of Isothermal Titration Calorimetry in Biotechnology”, Biotechnology Journal, 5, 85-98, (2010) (SCI)
  50. Chang Y*, Chu WL, Chen WY, Zheng J, Liu L, Ruaan RC, and Higuchi A, “A systematic SPR study of human plasma protein adsorption behavior on the controlled surface packing of self-assembled poly(ethylene oxide) triblock copolymer surfaces”, Journal of Biomedical Materials Research: Part A, 93, 400-408, (2010) (SCI)
 專利
  1. Wen-Yih Chen, Hardy Wai-Hong Chan, Yuh-Shyong Yang, Yi-Shao Liu and Li-Nai Tai“A method of detecting a plurality of biomarkers in a biological sample” US 62/648,239 (provisional)
  2. Wen-Yih Chen, Hardy Wai-Hong Chan, Yuh-Shyong Yang and Ming-Yu Lin “Method for quantitatively profiling nucleic acids” US 15/825,575(USA); EP17204174.1 (Europe); 2017-227744 (Japan); 10-2017-0161461(Korea); 10201709799S (Singapore); 255959 (Israel)
  3. Golden Tiao, Rung-Ywan Tsai, and Wen-Yih Chen “Biosensor and method of forming probe on solid surface of biosensor” US 2018/0149611 A1 (USA)
  4. 蔡經緯,彭于萱,謝馨儀,陳文逸,黃俊仁 “定向裝載系统及裝載粒子于井中的定向方法” (中華民國專利申請號105100355;獲准:公開號20175216)
  5. Ching-Wei Tsai, Hsin-Yi Hsieh, Yu-Hsuan Peng, Wen-Yih Chen and Chun-Jen Huang “Oriented loading systmes and method for orienting a particle loaded in a well” US 20160193602A1(USA); 16150313.1-1371 (EU); CN20160009299(China); 2016200047 (Australia); 2016-001507(Japan)
  6. Wen-Yih Chen, Hardy Wai-Hong Chan and Yuh-Shyong Yang “Partially Neutral Single-Stranded Oligonucleotide” European Patent Application, Patent application No. 16179734.5-1404 (US15/210,529/ IN201624024289/ JP2016-140287/KR10-2016-0090051/ China 2016 10557569.7/ Taiwan 105122498)
  7. Wen-Yih Chen, Hardy Wai-Hong Chan and Yuh-Shyong Yang “Detection Comprising Signal Amplifer” European Patent Application, Patent application No. 16179730.3-1401 (US15/210,513/ IN201624024288/ JP2016-140489/ KR10-2016-0090049/ China 201610557276.9/ Taiwan 105122465)
  8. Wen-Yih Chen, Hardy Wai-Hong Chan and Yuh-Shyong Yang “DNA Methylation Detection” European Patent Office (EPO) Patent No. 3118332 (US15/215,515 /IN201624024259 /JP2016-140488 /KR10-2016-0090050/ TW 105122486 / China 201610557520.1)
  9. Wen-Yih Chen, Hardy Wai-Hong Chan and Yuh-Shyong Yang “Method of using neutralized DNA (N-DNA) as surface probe for high throughput detection platform” 美國專利13/770,987 日期2013/02/19 (Allowed 08/08/2016) (USP9,481,905B2) 2016/11/01.
  10. Wen-Yih Chen, Ruoh-Chyu Ruaan and Ching-Wei Tsai “Peptide Ligand with Antibody Selectivity and the Application Thereof” 美國專利2015.02.17 申請號:14/624,223
  11. 陳文逸,阮若屈,蔡經緯 “具抗體選擇性之胜肽配體及其應用”中華民國專利申請日:2014.08.18   申請號:103128353
  12. Wen-Yih Chen, Li-Chiao Chang, Ruoh-Chyu Ruaan and Ching-Wei Tsai “ Peptide Chromatographic purification assisted by combining of solubility parameter and solution conformation energy calculations” 美國專利US 8,933,196B2 Jan. 13, 2015
  13. 陳文逸 、楊裕雄、詹維康 “以 N-DNA作為高通量檢測平台的表面探針之用途及使用方法” 中華民國專利申請案號101141103 日期 2012/11/06
  14. 陳文逸、蔡章仁Apparatus and method for recognizing a person’s gaze 美國專利US 8,272,738B2 (2009/09/21~2029/09/21)
  15. 陳文逸、蔡章仁 視線察覺裝置及其方法 中華名國專利 發明第I 384383 號(2013/02/01~2029/03/02)
  16. 陳文逸、李文仁、張榮森、黃榮南、許景翔, 生物晶片之製造方法及其應用, 中華民國發明專利公告號:I308214 (2009/0401/~2022/09/09)
  17. 陳文逸、許景翔, 檢驗甲醇的方法與甲醇檢測載體的製作方法, 中華民國專利(申請號碼92113287), 中華民國 發明專利公告號:I249030 (2006/02/11~2023/05/15)
  18. 陳顯禎、林俊佑、簡汎清、黃崑財、胡文品、陳文逸、李冠卿、李文獻, 一種高靈敏度表面電漿共振感測器, 中華民國專利 (申請號碼921014837), 中華民國 發明專利公告號:586005 (2004/05/01)
  19. Chen SJ, Lin GY, Chien FC, Hu WP, and Chen WY, A nanoparticle-enhanced ultrahigh-sensitivity surface plasmon resonance biosensor, U.S. Patent Pending No. 10/660,833 (submitted on March, 2003.11.)
  20. 陳顯禎、蘇園登、黃崑財、易政男、施至鴻、李文獻、李冠卿、陳文逸, 攜帶式表電漿共振與表面強化拉曼散射光電系統及其感測方法, 中華民國 發明專利公告號:I229734 (告號日期:2004/03/01)
  21. 辛裕明、蔡章仁、陳文逸, 偵測核酸雜交反應的生物晶片與偵測蛋白質的生物晶片及其偵測方法, 中華民國 發明專利公告號:I293115 (告號日期:2008/2/1)
  22. 曹嘉文、陳文逸, 一種具有分離、質譜轉移與質譜檢測功能的新型分析晶片, 中華民國 發明專利 (申請號碼099132059)
  23. 曹嘉文、陳文逸, 一種高產量、迅速且低成本的奈微米結構製造技術, 中華民國 發明專利 (申請中)
  24. Chang Y, Ruaan RC, Chen WY, Higuchi A, Chaing YC, Lai JY ” Low biofouling filtration membranes and their forming method” USA, US8062751B2(2011/11/22)
  25. 陳文逸、蕭伊迪、樋口亞紺” 一種利用核適體與核適體-鉑複合物於分子檢測之新方法” 中華民國, (申請中)
  26. Chang JY, Chen WY, Chien CC, Lin SF “Metal Buffer Layer Assisted Guided Mode Resonance Biosensor” USA (Pending No. 13/323,284) (Jan. 31, 2013)
  27. 張正陽、陳文逸、簡志誠、林聖富.“具金屬緩衝層之波導共振生物感測器” 中華民國, (申請號100125528)
  28. Chen WY, Chang LC, Ruaan RC “Peptide Chromatographic Purification Assisted by Combining of Solubility Parameter and Solution Conformation Energy Calculations” USA, (Patent Application, United States Patent Application 20120296068 2012)
  29. Chang L-C and Chen WY,. An Efficient Chromatographic Method for Purification. (United States Provisional Patent Application, 2011)
  30. 張雍, 阮若屈, 陳文逸, 樋口亞紺,江衍徹,賴君義; “低結垢含氟過濾膜及其形成方法 Low biofouling filtration membranes and their forming method”, 美國專利, 11/963,406 (申請日期2007年12月21日; 專利獲準2011年11月22日「證書號 US8,062,751 B2」
  31. 張雍, 阮若屈, 陳文逸, 樋口亞紺,江衍徹,賴君義; “低結垢含氟過濾膜及其形成方法 Low biofouling filtration membranes and their forming method”台灣專利, 97105269 (申請日期2008年2月15日)
  32. 張雍, 陳文逸; “抗生物結垢非離子型-兩性離子型共聚物/Antibiofouling nonionic-zwitterionic copolymer”  美國專利 (US 8,288,472B2) Oct.16/2012;
  33. 張雍, 陳文逸; “抗生物結垢非離子型-兩性離子型共聚物/Antibiofouling nonionic-zwitterionic copolymer” 台灣專利, 098145931 (申請日期2009年12月30日) ;
  34. 張雍, 陳文逸; “抗生物結垢非離子型-兩性離子型共聚物/Antibiofouling nonionic-zwitterionic copolymer” 中國專利, 201010623238.1 (申請日期2009年12月28日)
  35. 張雍, 阮若屈, 江衍徹,陳文逸 ; “抗生物分子沾黏塗佈劑設計方法”, 美國專利 (預計申請日期2012年3月); 台灣專利 (預計申請日期2012年4月)
  36. 張雍, 阮若屈, 江衍徹,陳文逸“抗生物沾黏之塗佈組成物、抗生物沾黏薄膜及抗生物沾黏薄膜之製造方法”in preparation 宇騰國際