
信箱:tulee@cc.ncu.edu.tw
研究室:工程一館 E237B
實驗室:生物啟發材料與高速材料篩選實驗室 E231
學歷
美國紐約大學 化學學士,1990年
美國柯柏高等科學藝術聯盟學院 化工學士,1990年
美國柯柏高等科學藝術聯盟學院 化工碩士,1993年
美國普林斯頓大學 化工博士,2000年
研究領域:有機分子結晶工程、藥物工程、生物礦化
經歷
美國必治妥施貴寶公司(Bristol-Myers Squibb)醫藥研究部門研究員,1999~2003
國立中央大學化學工程與材料工程學系助理教授,2004~2008
國立中央大學化學工程與材料工程學系副教授,2008~2011
國立中央大學化學工程與材料工程學系系主任,2017~2020
國立中央大學化學工程與材料工程學系教授,2011~至今
美國紐約聖若望大學製藥科學系訪問教授,2016/06-2016/09
國立中央大學化學工程與材料工程學系特聘教授, 2025~2027
研究背景
我們團隊的研究主軸為簡單有機分子、製藥工程及生物礦化的結晶,並運用由下而上(bottom-up)的純化製造方法進行研究。特別著重於功能性結晶材料的附加價值提升、大規模量產製造及產品的再現性等議題,此外,透過生物啟發及建立一套工程參數的高速篩選平台,應用於(1)Bio-mineralization,(2)Chiral Resolution,(3)Circular Economy,(4)Co-crystallization,(5)Hydrothermal process,(6)Polymorphism,(7)Reaction crystallization,(8)Salt formation,(9)Spherical crystallization,及(10)Wet Granulation.
論文著作
1. Aksay, I. A.; Chun, C. M.; Lee, T. Mechanisms of BaTiO3 Formation by Hydrothermal Reactions. In Proc. The Second Int’l Conf: On Solvothermal Reactions; Committee of Solvothermal Technology Institute: Takamatsu, Kagawa, Japan, 1996; pp 35-41.
2. Lahiri, J.; Xu, G.; Lee, T.; Dabbs, D. M.; Yao, N.; Aksay, I. A.; Groves, J. T. Biomimetic Fabrication of Material-The Minimalist Approach. SPIE Proc. 1996, 2716, 317-323.
3. Lee, T.; Yao, N.; Aksay, I. A. Nanoscale Patterning of Barium Titanate on Block Copolymers. Langmuir. 1997, 13(14), 3866-3870.
4. Lee, T.; Yao, N.; Aksay, I. A. Nanoscale Patterning of BaTiO3 on Block Copolymers. In Proc. Microscopy and Microanalysis; Bailey, G. W.; Dimlich, R. V. W.; Alexander, K. B.; McCarthy, J. J.; Pretlow, T. P., Eds.; Springer-Verlag: New York, NY, 1997; pp 423-24.
5. Yao, N.; Trau, M.; Manne, S.; Nakagawa, N.; Lee, T.; Honma, I.; Aksay, I. A. Mesoscopic Silica Thin Films Via Template-Assisted Self-Assembly. In Microscopy and Microanalysis, Bailey, G. W.; Dimlich, R. V. W.; Alexander, K. B.; McCarthy, J. J.; Pretlow, T. P., Eds.; Springer-Verlag: New York, NY, 1997; pp 395-396.
6. Luther, E. P.; Chun, C. M.; Lee, T.; Aksay, I. A. In Situ Processing of Nanosize Polymer/BaTiO3 Dielectric Films. In Advances in Dielectric Ceramic Materials, Nair, K. M.; Bhalla, A. S., Eds.; The American Ceramic Society: Westerville, OH, 1998; pp 189-194.
7. Yao, N.; Ku, A. Y.; Nakagawa, N.; Lee, T.; Saville, D. A.; Aksay, I. A. Disorder-Order Transition in Mesoscopic Silica Thin Films. Chem. Mater. 2000, 12(6), 1536-1548.
8. Lee, T.; Aksay, I. A. Hierarchical Structure-Ferroelectricity Relationships of Barium Titanate Particles. Cryst. Growth Des. 2001, 1(5), 401-419.
9. Lee, T.; Yao, N.; Imai, H.; Aksay, I. A. Barium Titanate Nanoparticles in Block Copolymer. Langmuir. 2001, 17(24), 7656-7663.
10. Lee, T.; Lee, J. Drug-Carrier Screening on A Chip. Pharm. Tech. 2003, 27(1), 40-48.
11. Lee, T.; Lee, J. Particle Attrition by Particle-Surface Friction in Dryers. Pharm. Tech. 2003, 27(5), 64-72.
12. Yin, S. X.; Franchini, M.; Chen, J. L.; Hsieh, A.; Jen, S.; Lee, T.; Hussain, M.; Smith, R. Bioavailability Enhancement of A COX-2 Inhibitor, BMS-347070, from A Nanocrystalline Dispersion Prepared by Spray-Drying. J. Pharm. Sci. 2005, 94(7), 1598-1607.
13. Kim, S.; Lotz, B.; Lindrud, M.; Girard, K.; Moore, T.; Nagarajan, K.; Alvarez, M.; Lee, T.; Nikfar, F.; Davidovich, M.; Srivastava, S.; Kiang, S. Control of The Particle Properties of A Drug Substance by Crystallization Engineering and The Effect on Drug Production Formulation. Org. Process. Res. Dev. 2005, 9(6), 894-901.
14. Lee, T.; Hung, S. T.; Kuo, C. S. A Bio-Inspired Approach: Polymorph Farming on a Chip. Pharm. Technol. 2006, 30(3), 82-94.
15. Lee, T.; Kuo, C. S. Effects of Initial Average Particle Size on Tableting: Evaluating Predictive Tools for Crystal Engineers and Formulators. Pharm. Technol. 2006, 30(3), 110-120.
16. Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, Polymorphism, Crystallinity, and Crystal Habit of Acetaminophen and Ibuprofen by Initial Solvent Screening. Pharm. Tech. 2006, 30(10), 72-92.
17. Lee, T.; Hung, S. T.; Kuo, C. S. Polymorph Farming of Acetaminophen and Sulfathiazole on A Chip. Pharm. Res. 2006, 23(11), 2542-2555.
18. Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, Polymorphism, Crystallinity and Crystal Habit of Acetaminophen and Ibuprofen Part I. Pharmaceutical Canada. 2007, 8(1), 15-17.
19. 陳映秀、洪士婷、李度,界面科學與化工應用專輯製藥業的同質異相篩選的技術與回顧,化工技術,第十五卷,第一期,第82-87頁(2007)。
20. Lee, T.; Chen, Y. H.; Zhang, C. W. Solubility, Polymorphism, Crystallinity, Crystal Habit, and Drying Scheme of (R,S)-(±)-Sodium Ibuprofen Dihydrate. Pharm. Tech. 2007, 31(6), 72-87.
21. Lee, T.; Lin, M. S. Sublimation Point Depression of Tris(8-hydroxyquinoline)aluminum (III) (Alq3) by Crystal Engineering. Cryst. Growth Des. 2007, 7(9), 1803-1810.
22. Lee, T.; Lin, Y. S. Dimorphs of Sucrose. Int. Sugar J. 2007, 109(1303), 440-445.
23. Lee, T.; Hsu, F. B. A Cross-Performance Relationship between Carr's Index and Dissolution Rate Constant: The Study of Acetaminophen Batches. Drug Dev. Ind. Pharm. 2007, 33(11), 1273-1284.
24. Lee, T.; Hung, S. T. Cocktail-Solvent Screening to Enhance Solubility, Increase Crystal Yield, and Induce Polymorphs. Pharm. Tech. 2008, 32(1), 76-95.
25. 侯宏儒、謝翔宇、王業文、蘇彥成、張世佳、陳君達、陳正國、李度,熱分析與熱量計在藥物開發上之應用,化工技術,第八卷,第一八五期,第134-151頁(2008)。
26. Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, Polymorphism, Crystallinity and Crystal Habit of Acetaminophen and Ibuprofen Part II. Pharmaceutical Canada. 2008, 8(3), 19-25.
27. Lee, T.; Zhang, C. W. Dissolution Enhancement by Bio-inspired Mesocrystals: The Study of Racemic (R,S)-(+/-)-Sodium Ibuprofen Dihydrate. Pharm. Res. 2008, 25(7), 1563-1571.
28. Lee, T.; Chen, Y. H.; Wang, Y. W. Effects of Homochiral Molecules of (S)-(+)-Ibuprofen and (S)-(-)-Sodium Ibuprofen Dihydrate on The Crystallization Kinetics of Racemic (R,S)-(±)-Sodium Ibuprofen Dihydrate. Cryst. Growth Des. 2008, 8(2), 415-426.
29. Lee, T.; Hou, H. J.; Hsieh, H. Y.; Su, Y. C.; Wang, Y. W.; Hsu, F. B. The Prediction of The Dissolution Rate Constant by Mixing Rules: The Study of Acetaminophen Batches. Drug Dev. Ind. Pharm. 2008, 34(5), 522-535.
30. Lee, T.; Chang, S. C. Sublimation Point Depression of Small-Molecule Semiconductors by Sonocrystallization. Cryst. Growth Des. 2009, 9(6), 2674-2684.
31. 張世佳、陳君達、陳正國、彭鎮帆、林育琨、汪璞芸、李度,差之毫釐失之千里藥物研發過程中同質異構物的選擇指南,MD News 生技與醫療器材報導月刊,第一二五期,第41-45頁(2009)。
32. Lee, T.; Wang, Y. W. Initial Salt Screening Procedures for Manufacturing Ibuprofen. Drug Dev. Ind. Pharm. 2009, 35(5), 555-567.
33. Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone: Part 1 of 2. Pharm. Tech. 2009, 33(5), 62-72.
34. Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Initial Solvent Screening of Carbamazepine, Cimetidine, and Phenylbutazone: Part 2 of 2. Pharm. Tech. 2009, 33(6), 54-61.
35. Lee, T.; Chen, J. G. Biomimetic Gallstone Formation: Crystallization of Calcium Carbonate by The Evolving Taurocholate-Lecithin-Cholesterol Complex Lipid System. Cryst. Growth Des. 2009, 9(8), 3737-3748.
36. Lee, T.; Chang, G. D. Sucrose Conformational Polymorphism: A Jigsaw Puzzle with Multiple Routes to A Unique Solution. Cryst. Growth Des. 2009, 9(8), 3551-3561.
37. Lee, T.; Wang, P. Y. Screening, Manufacturing, Photoluminescence, and Molecular Recognition of Co-Crystals: Cytosine with Dicarboxylic Acids. Cryst. Growth Des. 2010, 10(3), 1419-1434.
38. Lee, T.; Peng, J. F. Photoluminescence and Crystal Structures of Chiro-Optical 1,1’-Bi-2-naphthol Crystals and Their Inclusion Compounds with Dimethyl Sulfoxide. Cryst. Growth Des. 2010, 10(8), 3547-3554.
39. Lee, T.; Lin, Y. K. The Origin of Life and The Crystallization of Aspartic Acid in Water. Cryst. Growth Des. 2010, 10(4), 1652-1660.
40. Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Spherical Crystallization for Lean Solid-Dose Manufacturing (Part I) Pharm. Tech. 2010, 34(3), 72-75.
41. Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Spherical Crystallization for Lean Solid-Dose Manufacturing (Part II) Pharm. Tech. 2010, 34(4), 88-103.
42. Lee, T.; Chang, G. D. Engineering Processing Properties of Acetaminophen by Cosolvent Screening.Pharm. Tech. 2010, 34(8), 61-68.
43. Lee, T.; Chang, S. C.; Peng, J. F. Tris(8-hydroxyquinoline)aluminum (III) (Alq3) nanowires templated from an eggshell membrane. Thin Solid Films 2010, 518(19), 5488-5493.
44. 蔡旻翰、陳政緯、林子淳、劉政鑫、林奕辰、李度,輾壓技術,特別企劃製藥技術,化工技術,第十八卷,第六期,第164-196頁(2010)。
45. Lee, T.; Lin, Y. C. Mimicking The Initial Development of Calcium Urolithiasis by Screening Calcium Oxalate and Calcium Phosphate Phases in Various Urinelike Solutions, Time Points, and pH Values at 37oC. Cryst. Growth Des. 2011,11(7), 2973-2992.
46. Lee, T.; Liu, Z. X.; Lee, H. L. A Biomimetic Nose by Microcrystals and Oriented Films of Luminescent Porous Metal-Organic Frameworks. Cryst. Growth Des. 2011, 11(9), 4146-4154.
47. Lee, T.; Tsai, M. H.; Lee, H. L. Riboflavin Chelated Luminescent Metal-Organic Framework: Identified by Liquid-Assisted Grinding for Large-Molecule Sensing via Chromaticity Coordinates. Cryst. Growth Des. 2012, 12(6),3181-3190.
48. Lee, T.; Chen, H. R.; Lin, H. Y.; Lee, H. L. Continuous Co-Crystallization as a Separation Technology: The Study of 1:2 Co-Crystals of Phenazine-Vanillin. Cryst. Growth Des. 2012, 12(12), 5897-5907.
49. 林宏祐、蔡孟勳、李弘霖、薛喻仁、陳鑫榮、蔡雅鈞、邱鈺秀、謝宥晟、李度,結晶工程在綠色科技上的應用,化工技術,第二十卷,第十二期,第78-89頁(2012)。
50. Cheng, S. L.; Lin, Y. H.; Lee, S. W.; Lee, T.; Chen, H.; Hu, J. C.; Chen, L. T. Fabrication of Size-Tunable, Periodic Si Nanohole Arrays by Plasma Modified Nanosphere Lithography an Anisotropic Wet Etching. Appl. Surf. Sci. 2012, 263, 430-435.
51. Cheng, S. L.; Hsu, T. L.; Lee, T.; Lee, S. W.; Hu, J. C.; Chen, L. T. Characterization and Kinetic Investigation of Electroless Deposition of Pure Cobalt Thin Films on Silicon Substrates. Appl. Surf. Sci. 2013, 264, 732-736.
52. Lee, T.; Lee, H. L.; Tsai, M. H.; Cheng, S. L.; Lee, S. W.; Hu, J. C.; Chen, L. T. A Biomimetic Tongue by Photoluminescent Metal-Organic Frameworks. Biosens. Bioelectron. 2013, 43, 56-62.
53. Lee, T.; Chen, J. W.; Lee, H. L.; Lin, T. Y.; Tsai, Y. C.; Cheng, S.L.; Lee, S. W.; Hu, J. C.; Chen, L. T. Stabilization and Spheroidization of Ammonium Nitrate: Co-crystallization with Crown Ethers and Spherical Crystallization by Solvent Screening. Chem. Eng. J. 2013, 225(1), 809-817.
54. Lee, T.; Lin, Y. K.; Tsai, Y. C.; Lee, H. L. Propagation of Biochirality: Crossovers and Nonclassical Crystallization Kinetics of Aspartic Acid in Water. Chirality 2013, 25(11), 768-779.
55. Chang, H. T.; Wu, B. L.; Lee, T.; Lee, S. W. Uniform SiGe/Si Quantum Well Nanorod and Nanodot Arrays Fabricated Using Nanosphere Lithography. Nanoscale Res. Lett. 2013, 8(1), 349.
56. Lee, T.; Lin, H. Y.; Lee, H. L. Engineering Reaction and Crystallization and The Impact on Filtration, Drying, and Dissolution Behaviors: The Study of Acetaminophen (Paracetamol) by In-process Controls. Org. Process Res. Dev. 2013, 17(9), 1168-1178.
57. Lee, T.; Chiu, Y. H.; Lee, H. L. Thermal Properties and Structural Characterizations of New Types of Phase Change Material: Anhydrous and Hydrated Palmitic Acid/Camphene Solid Dispersions. Thermochim. Acta. 2014, 575, 81-89.
58. Haung, S. H.; Twan, S. C.; Cheng, S. L.; Lee, T.; Hu, J. C.; Chen, L. T.; Lee, S. W. Influence of Al Addition on Phase Transformation and Thermal Stability of Nickel Silicides on Si(0 0 1). J. Alloy. Compd. 2014, 586, S362-S367.
59. Lee, H. L.; Lin, H. Y.; Lee, T. Large-Scale Crystallization of a Pure Metastable Polymorph by Reaction Coupling. Org. Process Res. Dev. 2014, 18(4), 539-545.
60. Lee, T.; Lee, Y.; Lee, H. L.; Syue, Y. R.; Chiu, Y. H.; Liou, J. Y.; Sun, Y. S. Bio-inspired Phase Change Materials Designed for High Specific Heat of Solid Phase. Thermochim. Acta. 2014, 591, 61-67.
61. Lin, P. Y.; Lee, H. L.; Chen, C. W.; Lee, T. Effects of Baffle Configuration and Tank Size on Spherical Agglomerates of Dimethyl Fumarate in A Common Stirred tank. Int. J. Pharm. 2015, 495(2), 886-894.
62. Lee, H. L.; Lee, T. Direct Co-crystal Assembly from Synthesis to Cocrystallization. CrystEngComm. 2015, 17(47), 9002-9006.
63. Lee, T.; Lin, T. Y.; Lee, H. L.; Chang, Y. H.; Tsai, Y. C. Biomimetic Taste Receptors with Chiral Recognition by Photoluminescent Metal-Organic Frameworks Chelated with Polyaniline Helices. Chem. Eur. J. 2016, 22(4), 1406-1414.
64. Chih, M. H.; Lee, H. L.; Lee, T. The Culprit of Gout: Triggering Factors and Formation of Monosodium
Uratemonohydrate. CrystEngComm. 2016, 18(2), 290-297.
65. Lee, T.; Tsai, Y. C.; Lee, H. L.; Chang, Y. H.; Lin, T. Y. Metal-Organic Framework Engineering: Directed Assembly from Molecules to Spherical Agglomerates. J. Taiwan Inst. Chem. Eng. 2016, 62, 10-20.
66. 李度、李弘霖、李之穎,新世紀的化學工程:化學工程在製藥過程中所扮演之角色及其發展,台灣化學教育,第十五期 (2016.9) (http://chemed.chemistry.org.tw/?p=20808)。
67. Lee, T.; Chang, Y. H.; Lee, H. L. Crystallization Process Development of Metal-Organic Frameworks by Linking Secondary Building Units, Lattice Nucleation and Luminescence: The Insight into Reproducibility. CrystEngComm 2017, 19(3), 426-441. (Back Cover Artwork)
68. Wang, C. L.; Yeh, K. L.; Chen, C. W.; Lee, Y.; Lee, H. L; Lee, T. A Quick-Fix Design of Phase Change Material by Particle Blending and Spherical Agglomeration. Appl. Energy 2017, 191, 239-250.
69. Lee, H. L.; Vasoya, J. M.; Marilia de Lima Cirqueira; Yeh, K. L.; Lee, T.; Serajuddin, A. T. M. Continuous Preparation of 1:1 Haloperidol–Maleic
Acid Salt by A Novel Solvent-Free Method Using a Twin Screw Melt Extruder. Mol. Pharmaceutics 2017, 14(4), 1278-1291.
70. Chen, C. W.; Lee, T. Round Granules of Dimethyl Fumarate by Three-in-One Intensified Process of Reaction, Crystallization, and Spherical Agglomeration in A Common Stirred Tank. Org. Process Res. Dev. 2017, 21(9), 1326-1339.
71. Yeh, K. L.; Lee, T. Intensified Crystallization Processes for 1:1 Drug-Drug Co-crystals of Sulfathiazole-Theophylline, and Sulfathiazole-Sulfanilamide. Cryst. Growth Des. 2018, 18(3), 1339-1349.
72. 麥進成、陳峙瑋、葉冠麟、李度,原料藥廠的角色:活性藥物成分的製程開發,化工會刊,第六十五卷,第一期,第4-7頁(2018)。
73. Chen, T.-H.; Yeh, K. L.; Chen, C. W.; Lee, H. L.; Hsu, Y. C.; Lee, T. Mixing Effect on Stoichiometric Diversity in Benzoic Acid-Sodium Benzoate Cocrystals. Cryst. Growth Des. 2019, 19(3), 1576-1583.
74. Damayanti, J. D.; Pratama, D. E; Lee, T. Green Technology for Salt Formation: Slurry Reactive Crystallization Studies for
Papaverine HCl and 1:1 Haloperidol–Maleic Acid Salt. Cryst. Growth Des. 2019, 19(5), 2881-2891.
75. Lee, T. Yeh, K. L.; You, J. X; Fan, Y. C.; Cheng, Y. S.; Pratama, D. E. Reproducible Crystallization of Sodium Dodecyl Sulfate·1/8 Hydrate by Evaporation, Antisolvent Addition, and Cooling. ACS Omega 2020, 5(2), 1068-1079.
76. Li, Z. H.; Yu, T.; Lee, T.; Kim, W. S. Cocrystallization of Caffeine–Maleic Acid in A Batchelor Vortex Flow. Cryst. Growth Des. 2020, 20(3), 1618-1627.
77. Pratama, D. E.; Hsieh, W. C.; Elmaamoun, A.; Lee, H. L.; Lee, T. Recovery of Active Pharmaceutical Ingredients from Unused Solid Dosage-Form Drugs. ACS Omega 2020, 5(45), 29147-29157.
78. Lepeltier, E.; Levet, V.; Lee, T.; Mignet, N.; Shen, J.; Fenniri, H.; Corvis, Y. Editorial: Supramolecular Nanomaterials for Engineering, Drug Delivery, and Medical Applications. Front Chem. 2020, 8, 626468. (DOI:10.3389/fchem.2020.626468)
79. Lee, H. L.; Chiu, C. W.; Lee, T. Engineering terephthalic acid product from recycling of PET bottles waste for downstream operations. Chemical Engineering Journal Advances, 2021, 5, 100079.
80. Yeh, K. L.; Lee, T. Selective formation of form II paracetamol through the assistance of paracetamol co-crystal as templates in a solution. CrystEngComm, 2021, 23(22), 3940-3945. (Back Cover Artwork)
81. Lini, F. Z.; Pratama, D. E.; Lee, T. Co-Crystallization Kinetics of 2:1 Benzoic Acid-Sodium Benzoate Co-Crystal: The Effect of Templating Molecules in A Solution. Crystals, 2021, 11(7), 812.
82. Chen, C. W.; Lee, H. L.; Yeh, K. L.; Lee, T. Effects of Scale-Up and Impeller Types on Spherical Agglomeration of Dimethyl Fumarate. Ind. Eng. Chem. Res, 2021,60(30), 11555-11567.
83. Lee, H. L.; Cheng, Y. S.; Yeh, K. L.; Lee, T. A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process. ACS Omega, 2021,6(24),15770-15781.
84. Pratama, D. E.; Hsieh, W. C.; Lin, K. Y.; Chen, Y. Y.; Lin, C. C.; Hu,Y. F.; Lee, T. Unconventional Separation of Arsenic Trioxide from Unused Aqueous Chemotherapeutic Agents by Direct Evaporative Crystallization. Sep Sci Technol, 2021, 56(15), 2634-2647.
85. Hsueh, J. C.; Yeh, K. L.; Lee, H. L.; Lee, T. Strategy for Polymorphic Control by Enzymatic Reaction and Antisolvent Crystallization: Effect of Aminoacylase on Metastable β-Glycine Formation. React. Chem. Eng. 2021, 6, 2292-2305. (Back Cover Artwork)
86. Pratama, D. E.; Yang, C. L.; Chen, Y. Y.; Lin, C. C.; Hu, Y. F.; Lee, T. Quick-fix Agarose Beads Impregnated with Hydrous Ferric Oxide for As(Ⅲ) Species Removal from Pharmaceutical Wastewater. Sep Sci Technol., 2022, 57(7), 1013-1029.
87. Tseng, J. D.; Lee, H. L.; Yeh, K. L.; Lee, T. Recyclable Positive Azeotropes for the Purification of Curcumin with Optimum Purity and Solvent Capacity. Chem Eng Res Des. 2022, 200-211.
88. Yeh, K. L.; Lee, H. L.; Lee, T. Crystallization of Form II Paracetamol with The Assistance of Carboxylic Acids Toward Batch and Continuous Processes. Pharmaceutics. 2022, 14(5),1099.
89. Yang, C. L.; Lee, H. L.; Lee, T. Saving Energy Upon Water Removal in Drying by Making The α-Polymorph of L-Glutamic Acid. Sep. Sci. Technol., 2022, 57(12), 1948-1965.
90. Lee, H. L.; Yang, C. L.; Lee, T. Shaping Particle Size Distribution of a Metastable Polymorph in Additive-Assisted Reactive Crystallization by The Taguchi Method. Cryst. Eng. Comm. 2022, 24, 7176-7192.
91. Tseng, Z. H.; Lee, H. L.; Wu, S. Y.; Yeh, K. L.; Lee, T. Development of Sustainable Reaction and Separation Processes for Amantadine and Amantadine Hydrochloride. Chem. Eng. Res. Des. 2022, 188, 393-405.
92. Lee, H. L.; Hung, Y. L.; Amin, A.; Pratama, D. E.; Lee, T. Green and Strategic Approach for Chiral Resolution by Diastereomeric Salt Formation: The Study of Racemic Ibuprofen. Ind. Eng. Chem. Res. 2023, 62, 1946−1957.
93. Pratama, D. E.; Lee, T. Recycling of Resolving Agent and Solvent by Water-based Reactions and Phase Diagrams: Chiral Resolution Study of Racemic Ibuprofen. Chem. Eng. Res. Des. 2023, 192, 12-27.
94. Lee, H. L.; Yang, C. L.; Lee, T. Correction: Shaping Particle Size Distribution of a Metastable Polymorph in Additive-Assisted Reactive Crystallization by the Taguchi Method. Cryst. Eng. Comm. 2023, 25, 692-692.
95. Ma, P.; Toussaint, B.; Roberti, E. A.; Scornet, N.; Santos Silva, A.; Castillo Henríquez, L.; Cadasse, M.; Négrier, P.; Massip, S.; Dufat, H.; Hammad, K.; Baraldi, C.; Gamberini, M. C.; Richard, C.; Veesler, S.; Espeau, P.; Lee, T.; Corvis, Y. New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties. Pharmaceutics, 2023, 15(4), 1102.
96. Lee, T.; Mo, J. Y.; Pratama, D. E.; Lee, H. L.; Chen, Y. H.; Huang, Y. H.; Henriquez, L. C.; Corvis, Y. Preparation of Nanosized Liquid-Like Clusters of Irinotecan Hydrochloride Trihydrate for Injection Concentrate to Reduce Carbon Footprint. Int. J. Pharm. 2023, 648, 123558.
97. Lee, T.; Peng, Y. K.; Lee, H. L.; Pratama D. E. Chemical Recycling Development of Poly(ethylene terephthalate) by Glycolysis and Cooling Crystallization with Water. Ind. Eng. Chem. Res. 2023, 62(46), 19873-19883.
98. Wang, J. C.; Lee, H. L.; Pratama D. E.; Lee, T. Accelerating the Drying Process by Spherical Agglomeration: The Case of Benzoic Acid. Ind. Eng. Chem. Res. 2023, 62(51), 22028-22042.
99. Vasoya, J. M.; Lee, H. L.; Lee, T. Serajuddin, A. T. M. Continuous Synthesis of Cinnarizine Salt with Malic Acid by Applying Green Chemistry Using Water-Assisted Twin Screw Extrusion. Mol. Pharmaceut. 2023, 20(10), 5160-5172.
100. Pratama, D. E.; Huang, C.-Y.; Lee, T. A Mathematically Simplified Solid–Solid–Liquid Ternary Phase Diagram with Tie-Lines for Early Process Development Validated by Chiral Resolution of Racemic Ibuprofen. Ind. Eng. Chem. Res. 2024, 63(23), 10397–10409.
101. Lee, H. L.; Chang, Y. W.; Hsiao, Y. T.; Wang, Y. H.; Yeh, K. L.; Lee, T. Size Enlargement by Semibatch Reactive Crystallization with Varying Reactant Addition Methods and Reaction Kinetics: The Study of Dicumarol. Chem. Eng. Res. Des. 2024, 208, 740-752.
102. Pratama, D. E.; Chen, Y.-H.; Lee, T. A Solid–Solid–Liquid Quasi-Ternary Phase Diagram Method for Multicomponent Solids Validated by Curcumin Purification Design. Ind. Eng. Chem. Res. 2024, 63(44), 19135–19152.
103. Wang, Y.-H.; Lee, H. L.; Lee, H.-M.; Pratama, D. E.; Lee, T. Process Development and Optimization of Alkaline Hydrolysis for Depolymerization in Chemical Recycling of Poly(ethylene 2,5-furandicarboxylate) (PEF) Using Full Factorial Design. Ind. Eng. Chem. Res. 2025, 64(10), 5729– 5742.
榮譽獎項
• 2009~2023 國立中央大學學術研究傑出獎
• 2017 台灣化學工程學會傑出論文獎
• 2014 國立中央大學資深優良教師獎
• 2012~2014 國立中央大學績優專利獎
• 2013~2014 輸送現象及其應用專題研討會研究精湛獎
• 2009以及2013 國立中央大學教學優良教師獎
• 2010 國立中央大學教師及研究人員服務優良獎
• 2010 李謀偉福聚教育基金會學術研究傑出教授獎
• 2007 國立中央大學研究優良教師獎
• 2006 國立中央大學服務優良教師獎
個人服務
• 2008 年台灣化學工程學會化工會刊編輯
• 新竹科學工業園區事業廢棄物再利用委員會委員
• 2010 年NCU-TIT Advanced Functional Materials Conference 籌備委員
• 2010 年Taiwan-Japan Symposium on Soft Materials 籌備委員
• 2013 年台灣化學工程學會60週年年會熱質傳操作學術委員
• 2014 年輸送現象及其應用專題研討會學術委員
• 2016 年輸送現象及其應用國際研討會暨第5屆輸送現象教育研討會大會主席
• 2016 年台灣化學工程學會教育委員會委員
• 2016 年財團法人李長榮福聚教育基金會第6屆學術研究傑出教授獎評審委員
• 2017 年科技部工程技術研究發展司化學工程學門複審會委員
• 2017 年8月中央大學化學工程與材料工程系系主任(至2020年7月)
• 2018 年台灣化學工程學會化工會刊編輯
• 13th International Workshop on Crystal Growth of Organic Materials (CGOM13), Scientific Committee
• 2021-2023 年 Taiwan Institute of Chemical Engineers Student Affairs Committee, Chairperson
• 2020-2023 年 Journal of Taiwan Institute of Chemical Engineers, Associate Editor
• 2022 年擔任 Asian Crystallization Technology Society, Scientific Committee
• 2023 年擔任 Asian Crystallization Technology Symposium, Conference Chair and Steering / Organizing Committee Member
• 2024 年擔任 the 15th International Workshop on Crystal Growth of Organic Materials (CGOM15), Steering / Organizing Committee Member
• 2024 年擔任 Taiwan Institute of Chemical Engineers Student Affairs Committee, Chairperson
• 2024年擔任TwIChE台灣化學工程學會71周年年會暨國科會化學工程學門成果發表會/新世代化工國際研討會學術委員
受邀演講
• Crystal Engineering of Acetaminophen by Initial Solvent Screening, Reaction Crystallization and Reaction Coupling. Workshop on Functional Crystallization Technology. (Jeju Island, Korea, 2018/02/07)
• Achieving Structural Purity of Crystalline Solids Reproducibly by Solvent-Based Industrial Crystallization in a Common Stirred Tank. Crystallization Seminar in Autumn 2019 (Sapporo, Japan, 2019/09/26)
• Recovery of Chemotherapeutic Agent, Painkillers, and Antibiotic Drug from Unused Pharmaceutical Products by Crystallization. 2020台灣化學工程學會67週年年會暨科技部化工學門成果發表會 (國立清華大學,2020/10/24)
• Separation Studies of Terephthalic Acid and L-glutamic acid for Chemical/Material Development. 2021台灣化學工程學會68週年年會暨科技部化學工程學門成果發表會/前瞻分子工程研討會 (高雄展覽館,2022/01/07)
• Advancements in Pharmaceutical Technologies Drug Substance & Drug Product演講,題目: Orchestration of API Polymorphism. 2022新藥產業供應聯盟(CMC Alliance)及台灣生物產業發展協會之深耕學院(Bio-Industry Academy) (線上座談會,2/17~2/18)
• Towards Sustainable Process and Product Development by Solution Crystallization. 2022台灣化學工程學會69週年年會暨國科會化學工程學門成果發表會&台、日、韓、捷化學工程國際研討會 (淡江大學守謙國際會議中心,2022/12/03)
工業/學術合作及實習
• 工業
(1) 李長榮化學工業股份有限公司 (LCY CHEMICAL CORP.) 擔任顧問(2014/08)
(2) 法德生技藥品股份有限公司(Pharmadax Inc.) 擔任顧問(2012~2014)
(3) 心悅生醫股份有限公司(SyneuRx International (Taiwan) Corp.) 擔任顧問(2015/07~2015/11)
(4) 生展生物科技股份有限公司(SYNGEN BIOTECH CO., LTD.) 擔任顧問(2013/09)
(5) 財團法人生物技術開發中心(DCB.) 擔任顧問(2023/06~2023/12)
• 學術合作
(1) 藥物循環經濟: 使用溶劑萃取和再結晶從各種藥物回收活性藥物成分
•委託單位: 台灣東洋藥品工業股份有限公司 (TTY Biopharm Company Limited)
(2) HEPES粉立體結晶參數最佳化
•委託單位:聚和國際股份有限公司(Hopax)