專任教師
黃俊仁 教授
學校分機：34221
信箱：cjhuang@ncu.edu.tw
研究室：工程一館 E304A
實驗室：分子工程實驗室 E301
詳細介紹

學校分機：34221
信箱：cjhuang@ncu.edu.tw
研究室：工程一館 E304A
實驗室：分子工程實驗室 E301
學歷：Ph.D MOLECULAR BIOPHYSICS, Johannes Gutenberg Universität Mainz, Germany, 2010.

研究領域：1.表面功能性自組裝分子設計；2.離子型高分子精準合成技術開發與生醫應用；3.智能型水凝膠於生醫與能源應用。

Publication list in Google Scholar :
https://scholar.google.com/citations?hl=en&user=K1aOU3gAAAAJ&view_op=list_works&sortby=pubdate

Molecular engineering is a growing discipline based on the concept of “bottom-up” principle. This is focused on designing and studying molecular properties, functions, and interactions to develop improved materials, systems, and processes tailored for specific applications. Briefly, the observable properties of a macroscopic system are modified by directly altering its molecular structure.
分子工程科學為基於「自下而上」設計理念的新興領域，著重於設計與測試分子性質、功能與作用，進而改善與優化材料、系統與程序，以滿足特定應用。簡而言之，透過直接改變分子結構來影響整體系統的可觀測性質。

Our group focuses on developing zwitterionic and electrolyte materials in the form of self-assembling small molecules and linear/crosslinked macromolecules for various applications, including medical coatings, drug delivery, hydrogels, functional biointerfaces, sustainability and green energy. We investigate the structure-property relationships of ionic materials in water, electrolytes, and biological systems, as outlined in the Hofmeister series from the 1880s–1890s. Based on these findings, we synthesize a variety of ionic materials to address contemporary challenges and to advance the materials science.
我們的團隊專注於開發雙離子材料和電解質材料，形式包括自組裝的小分子以及線性/交聯的大分子材料，用於各種應用領域，如醫療塗層、藥物遞送、水凝膠、功能性生物界面、永續材料與綠色能源。我們研究離子材料在水中、電解質和生物系統中的結－性質關係，這些關係對應著the Hofmeister series。根據這些研究成果，我們合成各種離子材料，以解決當代挑戰並推動材料科學的進步。

Specific applications are as follows :
具體應用如下：

Medical Coatings生醫塗層
To prevent biofouling—such as contamination, bacterial infection, and foreign body reactions—and to enhance the biocompatibility of medical devices, surface passivation is achieved through the modification of zwitterionic materials. Zwitterionic materials consist of equal amounts of cations and anions, which helps maintain charge neutrality and superhydrophilicity. This feature minimizes non- specific adsorption by avoiding endothermic electrostatic attraction and entropic dehydration. We have developed self-assembled coatings, including thiol-, silane-, and catechol-based small molecules, as well as anchorable zwitterionic polymers, for the modification of substrates such as glass, wafers, metals, plastics, oxides and tissues.
為了防止生物污染, 如污染、細菌感染和異物反應, 並提高醫療器械的生物相容性，通過修改雙離子材料來完成表面生物鈍化。雙離子材料由等量的陽離子和陰離子組成，有助於保持電荷中性和超親水性。這種特徵通過避免吸熱的靜電吸引和熵脫水來最小化非特異性吸附。我們已開發出自組裝塗層，包括基於硫醇、矽烷和兒茶酚的小分子，以及可固定的雙離子聚合物，用於對玻璃、晶圓、金屬、塑料、氧化物與人體組織等基材的修飾。

Self-Assembling Materials自組裝材料
Under certain circumstances, self-assembling materials enable the spontaneous formation of ordered nanostructures driven by secondary forces, such as hydrophobic interactions, π-π stacking, π-cation interactions, electrostatic attraction, coordinative interactions, hydrogen bonding, and so on. These materials have attracted significant attention due to their unique characteristics, including molecular-level control, ordered structures, high packing density, and fine surface modifications that tailor physicochemical properties. We have gained substantial fundamental insights into self-organization, structure-property relationships, and interfacial phenomena from zwitterionic self-assembling materials. Additionally, we address an important issue in silane chemistry by developing novel functional silatranes, which consist of a five-membered cage structure. The cage structure protects organic silanes from fast hydrolysis and achieve "controlled silanization," resulting in uniform, thin, and highly oriented siloxane coatings. Together, these materials have been applied in biosensors, drug delivery, antifouling coatings, anti-fogging, circulating tumor cell separation, theranostic applications, and oil-water separation.
在特定情況下，自組裝材料能夠自發形成由二級力驅動的有序奈米結構，例如疏水作用、π-π堆疊、π-陽離子作用、靜電吸引、配位相互作用、氫鍵等。這些材料因其獨特的特性而受到廣泛關注，包括分子級控制、有序結構、高密度封裝和精細的表面修飾，以調整物理化學性質。我們從雙離子自組裝材料中獲得了對自組織、結構－性質關係和界面現象的基本認識。此外，我們通過開發新型功能性氮矽三環材料，解決了矽烷化學中的一個重要問題，該材料具有五元籠結構。籠結構保護有機矽烷免受快速水解，達成 “可控矽烷化”，從而形成均勻、薄且高度定向的矽氧烷塗層。總體而言，這些材料已應用於生物感測器、藥物傳送、防污塗層、防霧、循環腫瘤細胞分離、治療診斷應用和油水分離。

Sustainable, Self-Healable and Biodegradable Materials永續自修復生物可降解材料
There is growing concern about the environmental pollution caused by plastic waste, which significantly affects nearly every marine and freshwater ecosystem worldwide. As a result, sustainable plastic materials are being developed for green chemistry and society. We have fabricated self-healing polymers by incorporating aliphatic/aromatic disulfide bonds and amino-yne click chemistry to create reversible dynamic covalent bonds, enabling spontaneous healing at room temperature without external stimuli. These self-healing polymeric networks have been applied to cell encapsulation, cell phantoms for molecular imaging, recovery, and remolding. Additionally, we have developed biodegradable materials for drug delivery and tissue engineering. These bio-inspired degradable materials are synthesized using natural building blocks and modified through environmentally friendly processes to support green chemistry.
人們越來越關注塑料廢料造成的環境污染，這些污染對全球幾乎所有海洋和淡水生態系統造成了重大衝擊。因此，我們正在開發永續塑料材料，以推動綠色化學和社會的發展。我們通過引入脂肪族/芳香族二硫鍵和氨基-炔基點擊化學製備了自癒型聚合物，從而創造了可逆的動態共價鍵，能夠在室溫下無需外部刺激自發修復。這些自癒合聚合物網絡已被應用於細胞包裹、分子成像的細胞模擬體、修復和重塑。此外，我們還開發了用於藥物遞送和組織工程的可生物降解材料。這些受生物啟發的可降解材料是使用天然構建單元合成的，並通過環保的方法進行改質，以達到綠色化學的目標。

Tough Zwitterionic Hydrogels強韌雙離子水凝膠
Hydrogel-based materials, known for their high water content, transparency, biocompatibility, and similarity to the extracellular matrix, have gained prominence in various biological applications, including drug delivery, 3D scaffolds, injectable tissue engineering, surgical adhesives, and tissue sealants. However, due to their highly swollen network in water, hydrogels typically exhibit brittle and soft mechanical properties. We are developing tough hydrogels through various approaches, such as nanocomposite, double network, and microgel techniques. Additionally, we are exploring pH, ionic strength, and temperature-responsive functionalities to fabricate smart soft actuators. These hydrogels have been applied in a wide range of fields, including wound dressings, medical coatings, marine coatings, osmotic power generation, and thermoelectricity.
水凝膠材料因其高含水量、透明性、生物相容性及與細胞外基質的相似性而在各種生物應用中獲得重大發展，包括藥物遞送、三維支架、可注射組織工程、外科膠黏劑及組織黏著劑。然而，由於水中高度膨脹的網絡結構，水凝膠通常表現出脆性和柔軟的機械性質。我們通過多種方法開發出高強度水凝膠，例如納米複合材料、雙網絡技術和微凝膠技術。此外，我們還探索了材料的pH值、離子強度和溫度響應功能，用於開發智慧型軟質致動器。這些水凝膠已應用於多個領域，包括傷口敷料、醫療塗層、海洋塗層、滲透發電及熱電材料等。
Industrial Projects :
Industrial Technology Research Institute (ITRI, Taiwan), Personal Genomics, Inc (PGI), Tri-Service General Hospital, Landseed Hospital, General Silicone co. Ltd., Hon Hai Precision Industry Co., Ltd., Office of Naval Research (ONR, USA), Coatmed Inc., Master & Frank Enterprise co. LTD., Formosa Plastics Co., Everlight Chemical, Shenmao Tech. Inc., Acrocyte Therapeutics Inc., Giga Solar Materials Corp.

 

Honors :

  • PhD scholarship from the Max-Planck Institute (Oct. 2007-Dec. 2008)
  • Travel grant from Ministry of Education, Taiwan (Europt(r)ode X, Prague, Czech Republic, March 28-31 2010)
  • Oral Presentation Award, Biomaterials & Controlled Release Society, Taiwan (Apr. 28th, 2012)
  • Domestic Scholar Visiting Fellowship, Academia Sinica (Taiwan), (Jul.-Aug. 2012)
  • Domestic Scholar Visiting Fellowship, Academia Sinica (Taiwan), (2013)
  • Excellent Young Investigator Award, The 3rd International Symposium of Materials on Regenerative Medicine, (Aug. 2014)
  • Startup entrepreneurship competition, Golden Metal Award 千里馬盃模擬創業實驗競賽，金牌獎 (Nov. 2014)
  • Young Investigator Award, The 5th Asian Biomaterials Congress (ABMC5) (May, 2015)
  • Excellent Teaching Award (傑出教學獎), College of Engineering, NCU (May, 2015)
  • Startup entrepreneurship competition, Bronze Metal Award千里馬盃模擬創業實驗競賽，銅牌獎 (Nov. 2015)
  • Innovation competition, The First Runner-Up財團法人林鏡釧教育基金會 第三屆矽膠創意應用設計競賽 第二名 (Dec. 2015)
  • Outstanding Research Award (學術研究傑出獎), National Central University. (Jan. 2016)
  • Outstanding Young Researcher Project (優秀年輕學者研究計畫), MOST, Taiwan. (July, 2016)
  • Innovation competition, Bronze Metal Award  2016光寶創新獎 銅質獎. (Sep. 2016)
  • Outstanding Technology Transfer Award (優良技轉獎), National Central University. (Oct. 2016)
  • Outstanding Research Award (學術研究傑出獎), National Central University. (Jan. 2017)
  • Outstanding New Faculty Award (傑出新進教員獎勵), National Central University (Jan. 2018)
  • Outstanding Young Researcher Project (優秀年輕學者研究計畫), MOST, Taiwan. (July, 2019)
  • 2019年化工傑作獎 <<論文題目"從離子特異性效應到抗沾黏雙離子材料">>, 台灣化學工程學會 (Nov. 2019)
  • Outstanding Research Award (學術研究傑出獎), National Central University. (Jan. 2020)
  • Outstanding Research Award (學術研究傑出獎), National Central University. (Jan. 2021)
  • Distinguished Professorship (特聘教授), National Central University. (Jan. 2022)
  • Prof. Shih-Yow Huang Award, Biotechnology and Biochemical Engineering Society of Taiwan黃世佑教授紀念獎, 台灣生物技術與生化工程學會. (Jun. 2022)
  • Outstanding Young Researcher Project (優秀年輕學者研究計畫), NSTC, Taiwan. (July, 2022)
  • Young Scholar Award, Taiwan Membrane Society, 優秀青年學者獎 台灣薄膜學會 (2023)
  • 國科會工程處112年度「產學合作計畫成果發表暨績效考評會」 特優獎，2023
  • 卓越研究促進方案：傑出論文貢獻獎, NCU, 2023
  • 卓越研究促進方案：優良產學貢獻獎, NCU, 2023
  • 第20屆榮總台灣聯合大學合作研究論文獎 第二名，2024

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