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Wen-Yih Chen, Professor

Wen-Yih Chen - Professor  & Vice President
陳文逸 教授 兼副校長
| Ph.D. in Chemical Engineering, Oklahoma State University, USA
Ext.: 34222
Office: Engineering Building 4, E3-302
Lab: Biomolecular Recognition Engineering Laboratory, E3-325
Email: wychen@ncu.edu.tw
chen logo
Professor Wen-Yih Chen Photo

Research Interests

Thermodynamics and Kinetics of Biorecognition Systems, Controlled Drug Release, Biomaterials for Stem Cell Purification and Culture, Biochips.

 

Dr. Wen-Yih Chen is currently a Distinguished Professor in the Department of Chemical and Materials Engineering and Institute of Biomedical Engineering, National Central University (NCU). He was the Chairman of the Department and was the Associate Dean of the Engineering School of NCU. He also was a visiting Professor of MIT, Monash University and U. of Washington, Seattle. His research emphases have been on understanding the thermodynamics and kinetics between biomolecular interactions. With the principle understanding of the molecular interactions, he has successfully elucidated some biochemical separations and protein folding disease phenomena in molecular level.

Currently, he has devoted his research resources in biosensor development, especially in gene sequencing and biomarkers detection by Field Effect Transistor (FET) and Surface Plasmon Resonance (SPR).

He has published more than 150 peer review papers and owned more than 40 patents, mostly in biosensor area. He is currently on the editorial board of Biotechnology Journal (SCI), Bioprocess and Bioengineering (SCI) and Atomic and Molecular Physics (SCI). He is one of the founders of a newly established company, Helios Bioelectronics Inc., Taiwan.

Awards & Honors

  • Fellow, Biotechnology and Biochemical Engineering Society of Taiwan (BEST) (2025)
  • Fellow, Taiwan Institute of Chemical Engineers (TwIChE) (2025)
  • Distinguished Academic Award, Association of Chemical Sensors in Taiwan (2022)
  • Journal of Taiwan Institute of Chemical Engineers: Best Paper Award (2021)
  • Distinguished Research Medal, Biotechnology and Biochemical Engineering Society of Taiwan (2019)
  • Distinguished Engineering Professor Award, Chinese Institute of Engineers (2019)
  • Outstanding Research Award, Ministry of Science and Technology (MOST), R.O.C. (2018)
  • Gold Medal, iENA Nuremberg International Trade Fair for Ideas, Inventions & New Products — Anti-biofouling Coating Composition, Anti-biofouling Membrane, and Manufacturing Method Thereof (2018)
  • Academic Service Award, Biotechnology and Biochemical Engineering Society of Taiwan (2017)
  • Distinguished Paper Contribution Award, National Central University (2024)
  • Excellent Teaching Award, National Central University (2022)
  • Outstanding Patent Award, National Central University (2008, 2012)
  • Outstanding Technology Transfer Award, National Central University (2009)

Publications

Journal (2015~present)

  1. Chia-shun Lee, Wen-Pin Hu, Wen-Yih Chen “Electric-field Assisted Silicon Nanowire Field Effect Transistor for the Ultra-low Concentration Nucleic Acid Detection” Biosensors and Bioelectronics, 268, 15, Jan. 2025, 116909 (https://doi.org/10.1016/j.bios.2024.116909)
  2. Yi- Jung Sung, Wei-Ting Cai, Yi-Ping Chen, Hardy Wai-Hong Chan, and Po-Hsiang Wang and Wen-Yih Chen “Specific and efficient knockdown of intracellular miRNA using partially neutralized phosphate- methylated DNA oligonucleic acid-loaded mesoporous silica nanoparticles” Journal of Materials Chemistry B, 6942-6499 (2024)(DOI Link)
  3. Cao-An Vu, Wen-Wang Yang, Hardy Wai-Hong Chan, and Wen-Yih Chen “An aptamer sandwich assay for protein biomarker detection by solution-gated silicon nanowire field-effect transistor systems” Microchemical Journal, 207 (2024), 112245 (https://doi.org/10.1016/j.microc.2024.112245)
  4. Hong-Yu Lin, Cao-An Vu, Wen-Yih Chen “Impact of Counterions on Detecting MicroRNA at Ultra-low Concentrations by Silicon Nanowire Field-Effect Transistor Biosensors” Transactions on NanoBioscience (IEEE) (under review, minor revision) (2024)
  5. Vu, V.-T.; Vu, C.-A.; Huang, C.-J.; Cheng, C.-M.; Pan, S.-C.; Chen, W.-Y. Intermittent Lysis on a Single Paper-based Device to Extract Exosomal Nucleic Acid Biomarkers from Biological Samples for Downstream Analysis. Microchimica Acta 191, 501 (2024). https://doi.org/10.1007/s00604-024-06566-z
  6. Wen-Pin Hu, Yong-Qi Yang, Chia-Hsuan Leeb, Cao An Vub, Wen-Yih Chen “Comparing top-gate and bottom-gate nanowire field-effect transistors on pH sensing with different salt concentrations and surface modification” Talanta 271, 125731 (2024)
  7. Lee, Chih-Ling; Vu, Cao-An; Vu, Van Truc; Cheng, Chao-Min; Chang, Yung; Chen, Wen-Yih “Integrating Sulfobetaine Methacrylate Hydrogel-Modified Cellulose Triacetate Filter into a Zwitterionized Tandem Membrane System for Exosome Isolation” ACS Applied Polymer Materials (2024) https://doi.org/10.1021/acsapm.3c02949
  8. Le Yen Nhi Phan, Thi Anh Nguyet Nguyen, Hong Long Chen, Wen-Yih Chen, Ching-Jen Yang, Fan-Ching Chien, Cheng-Yi Liu, and Kun-Yu Lai “Detecting glucose in cell culture medium by the surface-enhanced Raman scattering on InGaN quantum wells” Optics Continuum Vol. 2, No. 12 2509 Dec (2023)
  9. Cao-An Vu, Yi-Ting Su, Jui-Shen Wang, Chia-Yu Chang, Wen-Pin Hu, Chun-Jen Huang, Hardy Wai-Hong Chan, Wen-Yih Chen* “Comparing Surface Modification Methods for Silicon Nanowire Field-Effect Transistor Biosensors for Diagnosis Applications: A Case Study of Cardiac Troponin I” Colloids and Surfaces A: Physicochemical and Engineering Aspects Vol. 676, Part A 5 Nov. (2023)
  10. Wen-Pin Hu, Yi-Fang Lai, Tsao, Chia-Wen, Shin-Chen Pan, Chao-Min Cheng, Wen-Yih Chen* “Paper/PMMA hybrid device with a microvalve-controlled design for exosome isolation and analysis” Talanta. (https://doi.org/10.1016/j.talanta.2023.124851) (2023)
  11. Shin-Chen Pan, Chi-Hung Lai, Van-Truc Vu, Cao-An Vu, Chun-Jen Huang, Chao-Min Cheng *, Wen-Yih Chen * “Paper-based Exosomal MicroRNA-21 Detection for Wound Monitoring: A Proof of Concept and Clinical Validation Trial Study” International Journal of Molecular Science. 24(12), 9822 (2023)
  12. Darius Linge, Marius Gedgaudas, Andrius Merkys, Vytautas Petrauskas, Antanas Vaitkus, Algirdas Grybauskas, Vaida Paketuryte, Asta Zubriene , Audrius Zakˇsauskas, Aurelija Mickeviˇciu ̄te, Joana Smirnoviene, Lina Baranauskiene, Edita Cˇapkauskaite , Virginija Dudutiene, Ernestas Urnieˇzius, Aleksandras Konovalovas, Egidijus Kazlauskas, Kirill Shubin, Helgi B. Schio ̈th, Wen-Yih Chen, John E. Ladbury, Saulius Graˇzulis, Daumantas Matulis “PLBD: Protein–Ligand Binding Database of Thermodynamic and Kinetic Intrinsic Parameters” DATABASE - The Journal of Biological Databases and Curation (IF:4.462)(Accepted) (2023)
  13. Wen-Pin Hu, Yu-Ming Wu, Cao-An Vu, and Wen-Yih Chen＊ “Ultrasensitive detection of Interleukin 6 by using silicon nanowire field-effect transistors” Sensors 23(2), 625 (2023) (doi.org/10.3390/s23020625)
  14. Yi-Chen Tsai, Wen-Yih Chen, and Chi-cheng Chiu “Molecular Effects of Site-specific Phosphate-Methylated Primer on the Structure and Motions of Taq DNA Polymerase” Computational and Structural Biotechnology Journal 21, 1820-27 (2023) (DOI:10.1016/j.csbj.2023.02.043.)
  15. Po-Hsiang Wang, Tony Z Joa Ching-Wen Chang, Bertrand Chin-Ming Tan, Ya-Hui Chi, and Wen-Yih Chen* “Sensitive and Specific MicroRNA In Situ Hybridization Using Partially Methylated Phosphotriester Antisense DNA Probes” GEN Biotechnology 1 (5), (2022) DOI: 10.1089/genbio.2022.0023
  16. Hsin-Hsien Chen, Ming-Hung Hsu, Kun-Hung Lee, Wen-Yih Chen, and Shieh-Yueh Yang “Real-time changes in the AC magnetic susceptibility of reagents during immunomagnetic reduction assays” AIP Advances 12, 065220 (2022) (DOI:10.1063/5.0097706)
  17. Chi-Hung Lai, Chih-Ling Lee, Cao-An Vu, Van-Truc Vu, Yao-Hung Tsai, Wen-Yih Chen* and Chao-Min Cheng “Paper-Based Devices for Capturing Exosomes and Exosomal Nucleic Acids From Biological Samples” Frontiers in Bioengineering and Biotechnology (DOI: 10.3389/fbioe.2022.836082) (2022)
  18. Yu-Chao Lin, Wen-Yih Chen, Edwin En-Te Hwu, and Wen-Pin Hu “In silico selection of aptamer targeting SARS-CoV-2 spike protein” International Journal of Molecular Sciences 23, 5810. https://doi.org/10.3390/ijms23105810 (2022)
  19. Shu-Chiao Chou, Yi-Jyun Lai, Xiao-zhen Zhuo, Wen-Yih Chen*, and Si-Yu Li* “Increasing the λ-Red mediated gene deletion efficiency in Escherichia coli using methyl phosphotriester-modified DNA” Journal of the Taiwan Institute of Chemical Engineers 104297 (DOI: https://doi.org/10.1016/j.jtice.2022.104297 (2022)
  20. Cao-An Vu, Hsin-Ying Lai, Chai-Yu Chang, Hardy Wai-Hong Chan, and Wen-Yih Chen* “Optimizing Surface Modification of Silicon Nanowire Field-Effect Transistors by Polyethylene Glycol for MicroRNA Detection” Colloids and Surfaces B: Biointerfaces 209, 1112142 (2022)
  21. Vu, C.-A.; Pan, P.-H.; Yang, Y.-S.; Chan, H. W.-H.; Kumada, Y.; Chen, W.-Y. Combination of Aptamer Amplifier and Antigen-Binding Fragment Probe as a Novel Strategy to Improve Detection Limit of Silicon Nanowire Field-Effect Transistor Immunosensors. Sensors 21(2), 650 (2021) (doi:10.3390/s21020650.)
  22. Joana Smirnovienė, Alexey Smirnov, Audrius Zakšauskas, Asta Zubrienė, Vytautas Petrauskas, Aurelija Mickevičiūtė, Vilma Michailovienė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Lina Baranauskienė, Wen-Yih Chen, John E. Ladbury, and Daumantas Matulis “Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII” ChemistryOpen (Accepted) (2021) doi.org/10.1002/open.202100042
  23. Vaida Paketurytė, Vytautas Petrauskas, Asta Zubrienė, Olga Abian, Margarida Bastos, Wen-Yih Chen, Maria João Moreno, Georg Krainer, Vaida Linkuvienė, Arthur Sedivy, Adrian Velazquez-Campoy, Mark A. Williams and Daumantas Matulis “Uncertainty of protein–ligand binding constants: asymmetric confidence intervals versus standard errors” European Biophysics Journal 50, 661–670 (2021)
  24. Wen-Pin Hu, Yu-Chi Chen, Wen-Yih Chen* “Improve sample preparation process for miRNA isolation from the culture cells by using silica fiber membrane” Scientific Reports (2020) (10, Article number: 21132 (2020)
  25. Cao-An Vu, Ping-Hsian Pan, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Yoichi Kumada, and Wen-Yih Chen* “Improving Detection Limit of Silicon Nanowire Field-Effect Transistor Immunosensors by Combining Aptamer Amplifier and Antigen-Binding Fragment Probe” Sensors 2021, 21(2), (2021) 650; https://doi.org/10.3390/s21020650
  26. Cao-An Vu, Yuh-Shyong Yang, Hardy Wai-Hong Chan and Wen-Yih Chen* “Improved Biomarker Quantification of Silicon Nanowire Field-Effect Transistor Immunosensors with Signal Enhancement by RNA Aptamer: Amyloid Beta as a Case Study” Sensors and Actuators 329,15 129150 (2021)
  27. Wen-Yih Chen*, Daumantas Matulis, Wen-Pin Hu, Yi-Fang Lai, and Wei-How Wang “Studies of the Interactions Mechanism between DNA and Silica Surfaces by Isothermal Titration Calorimetry” Journal of the Taiwan Institute of Chemical Engineers 116, 62-66 (2020)
  28. Tai-Chih Kuo, Meng-Wei Wu, Wei-Chen Lin, Daumantas Matulis, Yuh-Shyong Yang, Si-Yu Li, Wen-Yih Chen* “Reduction of interstrand charge repulsion of DNA duplexes by salts and by neutral phosphotriesters - Contrary effects for harnessing duplex formation” Journal of the Taiwan Institute of Chemical Engineers (2020) (https://doi.org/10.1016/j.jtice.2020.02.023)
  29. Vu, C.-A.; Chen, W.-Y.* (2020): Predicting Future Prospects of Aptamers in Field-Effect Transistor Biosensors. Molecules 25, 680. https://doi.org/10.3390/molecules25030680
  30. Wen-Pin Hu, Hui-Ting Lin, Wen-Yih Chen and Jeffrey J.P. Tsai “A Study on the effect of an aptamer with an embedded phosphate-methylated nucleotide on the binding of a target molecule using molecular simulation” Frontier Computing (2019), pp 31-38 (https:// doi.org/10.1007/978-981-12-3250-4_4) (EI)
  31. Cao-An Vu, Wen-Pin Hu, Yuh-Shyong Yang, Hardy Wai-Hong Chan, and Wen-Yih Chen* “Signal Enhancement of Silicon Nanowire Field-Effect Transistor Immunosensors by RNA Aptamer” ACS Omiga (2019) DOI: 10.1021/acsomega.9b01264
  32. Cao-An Vu and Wen-Yih Chen* “Field-Effect Transistor Biosensors for Biomedical Applications: Recent Advances and Future Prospects” Sensors (2019), 19, 4214; DOI:10.3390/s19194214
  33. Wei-Cheng Chou, Wen-Pin Hu, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Wen-Yih Chen* “Neutralized chimeric DNA probe for the improvement of GC-rich RNA detection specificity on the nanowire field-effect transistor” Scientific Reports (2019) 9:11056 DOI: 10.1038/s41598-019-47522-9
  34. Tsai-Ling Li, Meng-Wei Wu, Chian-Hui Lai, Yu-Hsuan Chang, Li-Jen Su, Wen-Yih Chen “Designed phosphate-methylated oligonucleotides as PCR primers for SNP discrimination” Analytical Biochemistry 411(17), 3871-3880(2019) (https://doi.org/10.1007/s00216-019-01865-4)
  35. Vaida Paketuryte, Vaida Linkuviene, Georg Krainer, Wen-Yih Chen and Daumantas Matulis “Repeatability, precision, and accuracy of the enthalpies and Gibbs energies of a protein-ligand binding reaction measured by isothermal titration calorimetry” European Biophysics Journal (2018) (https://doi.org/10.1007/s00249-018-1341-z)
  36. Tai-Chi Kuo, Yu-Chiang Huang, Daumantas Matulis and Wen-Yih Chen* “Molecular Self-Interactions of Ribonuclease A Revealed by Isothermal Titration Calorimetry and Self-Interaction Chromatography - Effects of Anisotropy of Protein Surface Charge” Journal of the Taiwan Institute of Chemical Engineers 96, 74–81 (2019)
  37. Lina Baranauskiene, Tai-Chih Kuo, Wen-Yih Chen* and Daumantas Matulis “Isothermal titration calorimetry for characterization of recombinant protein” Current Opinion in Biotechnology, 55, 9-15 (2018) (IF: 8.330) (5/407: Biomedical Engineering)
  38. CJ Huang, ZE Lin, YS Yang, H W-H Chan, W.-Y. Chen* “Neutralized Chimeric DNA Probe for Detection of Single Nucleotide Polymorphism on Surface Plasmon Resonance Biosensor” Biosensors and Bioelectronic 99, 170-175 (2018) (2/76: Chemistry, Analytical)
  39. WP Hu, CC Tsai, YS Yang, H W-H Chan and WY Chen* “Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as a probe” Scientific Reports (2018) 8:12598 (IF:4.122) (12/64: Multi-disciplinary Science)
  40. Hui-Ting Lin, Wei Yang, Wen-Yu Su, Chun-Ju Chan, Wen-Yih Chen, Jeffrey J. P. Tasi and Wen-Pin Hu “Study on the Binding Ability of Truncated Aptamers for the Prostate Specific Antigen Using Both Computational and Experimental Approaches” FC 2017, LNEE 464, pp. 46–55, (2018) (https://doi.org/10.1007/ 978-981-10-7398-4_5)
  41. W.-Y. Chen, N. H. Ma, T. L. Li, L. J. Su and Y. H. Chang “MicroRNA in situ hybridization with phosphate-methylated oligonucleotides (nDNA) probe” New Biotechnology 44, 147 (2018) (https://doi.org/10.1016/j.nbt.2018.05.1130)
  42. Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Jeffrey J.P. Tsai, and Wen-Pin Hu “The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen” BioMed Research International, doi.org/10.1155/2017/5041683 (2017)
  43. Vaida Linkuviene, Georg Kranier, Wen-Yih Chen and Daumantas Matulis “Isothermal titration calorimetry for drug design: Precision of enthalpy and binding constant measurements and comparison of the instruments” Analytical Biochemistry 515, 61-64 (2016)
  44. Tzu-Cheng Sung, Wen-Yih Chen, Pramod Shah and Chien-Sheng Chen “Replaceable liposomal aptamer for the ultrasensitive and rapid detection of biotin” Scientific Report. DOI:0.1038/srep21369 (2016)
  45. Tai-Chih Kuo, Ching-Wei Tsai, Peng-Chen Lee, Wen-Yih Chen* “Revisiting the streptavidin–biotin binding by using an aptamer and displacement isothermal calorimetry titration” J. Mol. Recog. 28, 125-128 (2015)
  46. CW Tsai, WW Hu, CI Liu, RC Ruaan, BC Tsai, SL Jin, Y Chang, WY Chen* “The consideration of Indolicidin modification to balance its hemocompatibility and delivery efficiency” International Journal of Pharmaceutics494(1) 498-505 (2015)
  47. WP Hu, J V Kumar; CJ Huang, WY Chen* “Computational selection of RNA aptamers against angiopoietin-2 and experimental evaluation” Biochemical and Biomedical Research International, 1-8, (2015)

Patents

  1. Wen-Yih Chen, Wen-Ren Li, Rong-Seng Chang, Rong-Nan Huang, Jing-Xiang Xu, "Manufacturing Method of Biochips and Their Applications", ROC Patent (Application No. 91120544), Publication No. 200622244 (2006/07/01)
  2. Wen-Yih Chen, Jing-Xiang Xu, "Method for Methanol Detection and Preparation of Methanol Detection Carrier", ROC Patent (Application No. 92113287), Publication No. I249030 (2006/02/11)
  3. Shean-Jen Chen, Chun-Yu Lin, Fan-Ching Chien, Kun-Cai Huang, Wen-Pin Hu, Wen-Yih Chen, Kuan-Ching Lee, Wen-Shien Lee, "A High-Sensitivity Surface Plasmon Resonance Sensor", ROC Patent (Application No. 921014837), Publication No. 586005 (2004/05/01)
  4. Chen SJ, Lin GY, Chien FC, Hu WP, and Chen WY, "A nanoparticle-enhanced ultrahigh-sensitivity surface plasmon resonance biosensor", U.S. Patent submitted on March, 2003.11.
  5. Shean-Jen Chen, Yuan-Deng Su, Kun-Cai Huang, Cheng-Nan Yi, Chih-Hung Shih, Wen-Shien Lee, Kuan-Ching Lee, Wen-Yih Chen, "Portable Surface Plasmon Resonance and Surface-Enhanced Raman Scattering Optoelectronic System and Sensing Method", ROC Patent Publication No. I229734 (2004/03/01)
  6. Yuh-Ming Hsin, Chang-Jen Tsai, Wen-Yih Chen, "Biochip for Detecting Nucleic Acid Hybridization and Protein Detection, and Detection Methods Thereof", ROC Patent Publication No. I293115 (2008/2/1)
  7. Chia-Wen Tsao, Wen-Yih Chen, "A Novel Analytical Chip with Separation, Mass Transfer, and Mass Spectrometry Detection Functions", ROC Patent (Pending)
  8. Chia-Wen Tsao, Wen-Yih Chen, "A High-Throughput, Rapid, and Low-Cost Fabrication Technology for Nano/Microstructures", ROC Patent (Pending)
  9. Chang Y, Ruaan RC, Chen WY, Higuchi A, Chaing YC, Lai JY ” Low biofouling filtration membranes and their forming method” USA, US8062751B2(2011/11/22)
  10. Wen-Yih Chen, Yi-Di Xiao, Akon Higuchi, "A Novel Method for Molecular Detection Using Aptamers and Aptamer-Platinum Complexes", ROC Patent, (Pending)
  11. Chang JY, Chen WY, Chien CC, Lin SF “Metal Buffer Layer Assisted Guided Mode Resonance Biosensor”USA, (Pending)
  12. Cheng-Yang Chang, Wen-Yih Chen, Chih-Cheng Chien, Sheng-Fu Lin, "Guided Mode Resonance Biosensor with Metal Buffer Layer", ROC Patent, (Pending)
  13. Chen WY, Chang LC, Ruaan RC “Peptide Chromatographic Purification Assisted by Combining of Solubility Parameter and Solution
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